factors that increase reverse cholesterol transport

13, 48–60. Effect of exercise on reverse cholesterol transport (RCT). This group is mainly composed of cyanidin, peonidin, pelargonidin, malvidin, delphinidin, and petunidin. They found that this training routine positively alters the lipid profile of sedentary individuals, with a significant decrease in total cholesterol, increase in HDL-c, and elevation in the oxidized concentration of LDL-c (LDLox). (2015). | Effect of exercise on reverse cholesterol transport (RCT). Changes in HDL-c concentrations after 16 weeks of combined training in postmenopausal women: characteristics of positive and negative responders. Four Prospect. Independent reviewers verified titles and abstracts and relevant full-text articles following specific inclusion criteria. When activated, it moves to the nucleus and connects to its promoter region, where it transcribes genes related to oxidative metabolism and transport of lipoproteins, such as ABCA1 and Apo A-1. Int. In addition, the PPAR agonist was effective in increasing HDL-c and decreasing LDL-c. 116, 3090–3100. Nutr. doi: 10.1007/s11745-012-3685-y, Vinagre, J. C., Vinagre, C. G., Pozzi, F. S., Slywitch, E., and Maranhão, R. C. (2013). However, none of the studies were conclusive on confirming the role of bioactive compounds in increasing HDL-c. Bai Y, Yuan P, Zhang H, Ramachandran R, Yang N, Song J. Poult Sci. A replacement of carbohydrates by lipids, especially saturated fatty acids, have demonstrated better results concerning HDL-c levels. (2014). The action of the catechins is related to an increase in serum PON 1 activity and a decrease in ApoB lipoprotein oxidation in diabetic rats (Tas et al., 2005). Drugs 14:E35. (1) The liver synthesizes Apo A-1 that enters the bloodstream. The concept of reverse cholesterol transport is based on the hypothesis that HDL displays an cardioprotective function, which is a process involved in the removal of excess cholesterol that is accumulated in the peripheral tissues (e.g., macrophages in the aortae) by HDL, transporting it to the liver for excretion into the feces via the bile. Interestingly, recent studies have indicated that sialic acids have antioxidant activities [4–6], and exogenous NANA could be employed as a therapeutic option in some diseases. doi: 10.1038/ncpendmet0397, Ghanbari-Niaki, A., Ghanbari-Abarghooi, S., Rahbarizadeh, F., Zare-Kookandeh, N., Gholizadeh, M., Roudbari, F., et al. Drug Insight: mechanisms of action and therapeutic applications for agonists of peroxisome proliferator-activated receptors. 2016. Hernández-Alonso, P., Salas-Salvadó, J., Baldrich-Mora, M., Mallol, R., Correig, X., and Bulló, M. (2015). Several studies have investigated non-pharmacological strategies of prevention and treatment of dyslipidemia, such as enhanced HDL-c by increased physical activity, improved diet, or a combination of these in different populations. Cardiol. On the other hand, there is an inverse relationship between high-density lipoprotein cholesterol (HDL-c) and incidence of coronary heart disease. doi: 10.1016/j.amjcard.2010.12.014, Cavelier, C., Lorenzi, I., Rohrer, L., and von Eckardsten, A. 7, 632–642. The high concentration of low-density lipoprotein cholesterol (LDL-c) is an independent risk factor for coronary artery disease. Eur. (South Dartmouth, MA: MDText.com, Inc.). In this perspective, the positive relationship between aerobic exercise training and lipid profile regulation is associated with enzymatic modulation of Lecithin-cholesterol acyltransferase (L-CAT), which is involved in the esterification of cholesterol during the RCT. Epub 2020 Jun 23. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). Endocrinol. Exercise intensity modulation of hepatic lipid metabolism. Food Sci. Nutr. In addition, exercise caused elevation of oxidized LDL-c concentrations, which resulted in the activation and positive regulation of PPAR-γ and LXRα transcription factors in leukocytes, and consequently, increase in gene expression of cholesterol-related reverse transporters to HDL-c, such as FAT-CD36, ABCA1, and ABCG1. J. Exerc. Regul. : 14-05204-EF-1. J. Med. Plasma Proteome Profiling of Coronary Artery Disease Patients: Downregulation of Transthyretin-An Important Event. The authors shown that men with HDL cholesterol of 2.5–2.99 mmol/L (97–115 mg/dL) increased 1.36 (95% CI: 1.09–1.70) all-cause mortality and HDL cholesterol ≥ 3.0 mmol/L (116 mg/dL) were associated with a significant increase of 2.06 (1.44–2.95). doi: 10.1093/eurheartj/ehx163. (2016) also verified the influence of recovery interval (30 vs. 90 s) after four sets of squats and four sets of horizontal bench press, performed with 90% of 1 repetition maximum (1-RM) until momentary fatigue in previously trained subjects. doi: 10.1002/mnfr.201500030. doi: 10.1007/s11789-015-0074-0. Lipoproteins are complex structures composed of lipids and proteins that transport lipids through body fluids. The high concentration of low-density lipoprotein cholesterol (LDL-c) is an independent risk factor for coronary artery disease. Discovery of the lipoproteins, the role in fat transport and their significance as risk factor. doi: 10.1210/jc.2013-1180, Taku, K., Umegaki, K., Sato, Y., Taki, Y., Endoh, K., and Watanabe, S. (2007). Commun. Additionally, the possibility of controlling different training variables, such as type, intensity and recovery interval, can be used to maximize the benefits of exercise in promoting cardiovascular health. J. Cardiol. Few studies have examined the effect of physical training on SR-B1 modulation. Eur. Metab. 361, 841–846. Sports Med. A randomized, double-blind, crossover, controlled trial. -, Butcher L. R., Thomas A., Backx K., Roberts A., Webb R., Morris K. (2008).

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